Role of miRNAs in Immune Regulation And Bacterial Infections

Micro RNAs (miRNAs) are small noncoding that regulate gene expression at the post-transcriptional level. The miRNA in RNA-induced silencing complex acts as a guide strand and binds target mRNA. Subsequently, is silenced either by cleaving mRNA or repressing translation. Since discovery of first three decades ago, more than 2000 human miRNAs have been discovered. It known to hundreds genes various physiological pathophysiological processes, including development function immunologically essential cells. miR-155 plays vital role T helper 1, 17, regulatory miR-24 positively regulates cells, whereas miR-23 27 negative effect. miR-223 differentiation neutrophils monocytes. bacterial infections came light 2006 after discovering miR-163 regulator defense response Arabidopsis thaliana infected with Pseudomonas syringae. During infection host, aberrant several was found be most commonly dysregulated such Helicobacter pylori, Staphylococcus aureus, Listeria monocytogenes, Mycobacterium tuberculosis, Chlamydia trachomatis. Therefore, can utilized diagnostic prognostic tool for infections. J Microbiol Infect Dis 2022; 12(4):1-7.